Patient: Young woman 24 years of age, followed for lupus and antiphospholipid antibody syndrome, hospitalized for chest pain and dyspnea; electrocardiogram recorded on arrival at the emergency room;
Case Summary
0 of 1 questions completed
Questions:
- 1
Information
You have already completed the case before. Hence you can not start it again.
Case is loading…
You must sign in or sign up to start the case.
You must first complete the following:
Results
Results
0 of 1 questions answered correctly
Time has elapsed
Categories
- Not categorized 0%
-
Pulmonary embolism
ECG 1A: Sinus tachycardia (132 bpm); normal PR interval, narrow QRS with right conduction delay pattern; S1q3 pattern; flat T-wave in lead III; absence of major repolarization disorders;An angioscanner confirmed the diagnosis of non-massive pulmonary embolism; initiation of treatment with a curative dose of LMWH;
ECG 1B: Tracing recorded 2 days after the initial tracing; slowing of the sinus rate (103 bpm); decrease in the size of the S wave in lead I and regression of the right conduction delay pattern;
Comments: Pulmonary embolism is defined by the abrupt closure, total or partial, of one or more branches of the pulmonary artery, in general by a fibrinocruoric thrombus. This is a frequent, serious, life-threatening condition, yet often undiagnosed because of the polymorphism of clinical signs. In this young patient followed for lupus and an antiphospholipid antibody syndrome, the diagnosis of pulmonary embolism was likely, given the evocative symptomatology; the angioscanner confirmed the presence of a pulmonary embolism without signs of severity.
The place of the electrocardiogram is relatively limited in the management of patients with pulmonary embolism. Indeed, the electrocardiogram offers no or very little contribution to the diagnosis, the electrical alterations are aspecific, inconsistent, incomplete and fleeting, and a normal aspect must never exclude the diagnosis of pulmonary embolism. Electrocardiographic changes are often short-lived and transient, hence the necessity to repeat the recordings. However, the electrocardiogram allows eliminating differential diagnoses in the setting of chest pain or dyspnea. In this patient, the electrocardiogram shows certain electrical signs that are not specific but suggestive of pulmonary embolism: sinus tachycardia, S1Q3 pattern, right conduction delay.
A pulmonary embolism is accompanied by a sudden systolic overload of the right ventricle caused by pulmonary artery occlusion. The resulting electrical abnormalities vary depending on the territory, of previous histories of embolism, the size of the thrombus, and the degree of obstruction. When the pulmonary embolism is not massive, the electrocardiogram is often normal and the changes may be limited to a few discrete signs or subtle changes from a previously recorded tracing with, in decreasing order of frequency, tachycardia, T-wave inversions in right precordial leads or in lead III, S1Q3 pattern and right axis deviation), displacement to the left of the transition, right conduction delay. Just as the nature of the electrical alterations, evolution over time can also be evocative: the S1Q3 pattern usually appears in the first 24 hours and disappears within a few days whereas the T-wave inversions in the right precordial leads are observed later but only regress after one to several weeks.
Take-home message: The electrocardiogram is not the best diagnostic tool for pulmonary embolism. Indeed, the electrical signs are not very sensitive since only one quarter of the patients (often in the severe forms) present a truly characteristic electrocardiogram. Each abnormality taken individually also has a low specificity, with the distinction between normal and pathological pathways often made on the basis of a comparison with previous or later tracings and searching for a compatible clinical right ventricular overload.
- 1
- Answered
- Review
-
Question 1 of 1
1. Question
What is(are) the probable diagnosis(es) given this clinical history and electrocardiogram?
CorrectIncorrect